Articles Published in 1997

Antiviral Agents Bulletin

Agouron's HIV Protease Inhibitor Shows Efficacy for HIV-Infection
Indinavir Triple Drug Therapy Effective in Advanced AIDS and Early HIV Patients
Phase III Trial with Controlled Release Acyclovir
Improved Survival and Cost Savings with HIV Protease Inhibitor Drug Combinations
Prophylactic Human Papillomavirus Vaccine Enters Trials
Combinations of HIV Protease Inhibitors Showing Promise
HIV NNRTI from DuPont Merck Showing Promise
Stem Cell Ribozyme Gene Therapy Enters Trials
Allelix Halts HIV and CMV Tat Inhibitor Development
Agouron Licenses Nelfinavir International Marketing Rights to Roche
ViroPharma Links with 3-Dimensional Pharmaceuticals
Oral Vaccine Delivery Companies Merge
Nanocrystal HIV Protease Inhibitor Delivery System
Ampligen in Phase II Trial for HIV-Infection
VIMRx Acquires Ribozyme Co.; Starts Trial with Hypericin for HCV
HIV Oligonucleotide Drug from Isis Enters Trials
GS 840 Enters Phase III Trials for HIV and CMV
HIV Immunotherapeutic Vaccine from Cytel Phase I/II Trials
Genetic Vaccine Companies Merge
Improved Saquinavir Soft Gel Formulation Trials
Oral Pediatric D4T Available
CMV Antisense Drug Enters New Trials
Early HIV Protease Inhibitor Treatment Extends Response
Steroidogenesis Inhibitor Phase II Trial for HIV-Infection
GS 4104 Entering Clinical Trials for Influenza
Oral PMPA and Cyclic Cidofovir Prodrugs
HIV NNRTI Nevirapine Safe with Protease Inhibitors
Cidofovir Enters Trials for Kaposi's Sarcoma Herpesvirus
HIV NNRTI MKC-442 Shows Indications of Efficacy
HGP-30 Heteroconjugate Peptide HIV Vaccine Preclinical Studies
Oral Ganciclovir Prodrug Shows Promise
Hepatitis B Antigen from Plants
Baxter Not Acquiring Immuno AG
U.S. National AIDS Strategy
NIH Panel Backs AZT During Pregnancy Despite Carcinogenicity Concerns
Warning on D4T/AZT Combination
Annual Review of Vaccine Progress Published
Federal Bio-Technology Transfer Internet Web Database
HIV Passive Immunization Available for Licensing
Transgenic Monoclonal Antibody Patent Dispute Settled
Companies License Flavivirus Vaccines from NIH
Igen Licenses HIV-1 p7 Assays from NIH
Hepatitis C Virus PCR Available for Licensing
Highlights of U.S. Patents
Nelfinavir Receives Accelerated Approval for HIV-Infection
Immune Modulator, Imiquimod Cream, Approved for Genital Warts
Ritonavir Approved for Pediatric Use
Foscarnet and Ganciclovir Combination Approved for CMV Retinitis
Humanized RSV Monoclonal Antibody, MEDI-493, Trial Results
Hepatitis G Virus Not a Serious Pathogen
Confirmatory Phase II Trial for GEM 91, an HIV Antisense Drug
Oral Live Rotavirus Vaccine Advances into Phase II Trials
HIV Antibodies Plus Immune Modulators Show Indications of Efficacy
Thalidomide Clinical Trials in HIV Patients
ÒIndustry Investment in HIV Vaccine ResearchÓ Report Published
HIV Drug To Be Marketed as a Nutritional Supplement
Gilead Files for Approval of Cidofovir Cream for Genital Herpes in AIDS Patients
HIV Immunotherapeutic Gene Therapy Trials Expanded
Reticulose To Be Studied Through CRADA with NCI
Demand for RSV Immune Globulin Outpaces Supply
Primary Immune Response to HIV Predicts Disease Progression
Influenza Vaccine Trial a Full Year Ahead of Schedule
Ampligen Shows Indications of Efficacy for Chronic Fatigue Syndrome
HIV Immune Globulin/Monoclonal Antibodies Combination Effective In Vitro
Lidakol Shows Indications of Efficacy for KaposiÕs Sarcoma
HIV Protease Inhibitor Comparative Efficacy Trial
Cell Genesys Acquires Somatix
HIV/Herpes Drug Marketing Deal for South America
Two-Step Viral Inactivated Factor VIII Approved
SPV-30, Herbal HIV Drug, Distribution Halted in U.S.
AccuSite Injectable Gel Has Problems with FDA Approval
New NIAID HIV Vaccine Grant Program
New NIH AIDS Research and Reference Reagent Program Catalog
New Internet Web Sites
New Books
New Meetings
Corixa and Pasteur Merieux Connaught Form Vaccine Adjuvant Collaboration
Highlights of U.S. Patents
Delavirdine Granted Accelerated Approval for HIV-Infection
Lamivudine Shows Efficacy for Chronic Hepatitis B in Phase III Trial
RSV Antibody Nosedrops Fail to Show Efficacy in Phase III Trial
Subcutaneous IL-2 Shows Efficacy and Safety for HIV-Infection
DDI/D4T May Be an Early HIV Treatment Alternative
Adenovirus Linked to Obesity
HIV Immune Globulin Development for Maternal Transmission Halted
HIV Zinc Finger Inhibitor Enters Trials
Expanded Access Programs for 1592U89
Another Trial Shows Promise for MEDI-493, RSV Monoclonal Antibody
Nelfinavir Efficacy After Ten Months Reported
Pregnancy Hormone Active Against HIV
Wyeth-Lederle Vaccines Collaborating with BioDelivery Sciences
Glaxo Wellcome Links with Affymetrix for HIV Database
Nonoxynol-9 Film Fails to Prevent HIV Transmission
Influenza Vaccine with Novel Adjuvant Advances Into Phase II Trials
Indinavir, MerckÕs HIV Protease Inhibitor, Finally Available in U.S. Pharmacies
Correction
Medicaid Coverage for HIV Drugs May Be Expanded
Generic Acyclovir Products Approved by FDA
FDA Approves Expanded Use Regimens for Inactivated Polio Vaccine
Extended Use of Intron A for Hepatitis C Approved
Condylox Gel Formulation Approved for External Genital/Perianal Warts
NIH Abandons HTLV-I Patent
Glaxo Wellcome Licenses Genital Herpes Vaccine from Cantab
Triangle Licenses MKC-442 HIV NNRTI
Interferon-Beta European Patent Revoked
SKB Licenses Adjuvant for HPV Vaccine
Highlights of U.S. Patents
Trial to Test Whether Treatment of First HSV Outbreak Can Halt Future Outbreaks
Antisense Drug, GEM 91, Shows Indications of Efficacy for HIV-Infection
Penciclovir Cream Launched in the U.S. for Oral Herpes
Treatment-Related T-Cell Increases May Not Help HIV-Infection
Oral Ganciclovir Shows Efficacy for Kidney Transplant CMV Prophylaxis
Cell Culture Influenza Vaccine Passes Phase I Trial; Nasal Vaccines Collaboration
Oral PMPA Enters Trials for HIV
MediChem Links with Malaysian State to Develop Calanolide A for HIV-Infection
Hybridon Links with the Institute of Human Virology
HIV Immunotherapeutic Vaccine Induces Chemokine Responses
Sequus Pharmaceuticals and Protein Sciences Link for Liposome-CD4
Large Trial Closed as AZT/3TC Arm Declared Suboptimal
Hybridon-Roche Collaboration Selects Lead HPV Antisense Drug
Genital Herpes Phase II Trial with Topical Virend Plus Acyclovir
Cidofovir Injection Approved in European Union
BCX-34, T-Cell Modulator, Enters Trial for HIV-Infection
HGP-30 HIV Vaccine/GM-CSF Adjuvant Trial
HGP 30 HIV Vaccine Induces Multiple Subtype Antibodies
Famciclovir Approved in U.K. for Suppression of Genital Herpes
Influenza Vaccine Use Up Among U.S. Elderly
Glaxo Wellcome Sells U.S. Rights to Ophthalmic Trifluridine
Structural Bioinformatics Links with CyberChemics for HCV Protease Inhibitors
Aviron Links with Medeva for Influenza Vaccine Production
Russia Starting HIV Vaccine Program
Phase II Prime-Boost HIV Vaccine Trial
GS 840 Enters Phase II Trials for Hepatitis B
Nevirapine Combination Safety Shown in Pediatric Trial
HIV May Be Becoming More Aggressive
PRO 2000 Shows Antiviral and Spermicidal Effects
Adjuvant Enhances Immune Response to HIV DNA Vaccines
New DNA Vaccine Company Forming
ViroPharma Links with Schwarz Pharma for Pleconaril Production
Poll Shows Popular Support for Medicaid AIDS Drug Coverage
Agouron and Nastech Link for Intranasal Rhinovirus 3C Protease Inhibitors
Agouron Receives FDA Letter Concerning Trial Press Release
Insufficient Data for Approval of Cidofovir Gel for Refractory HSV in AIDS Patients
Roche Submits NDA for Saquinavir Soft Gel Formulation
Ampligen Trial for CFS Includes Cost-Recovery
Retrovir (AZT) Available in 300 mg Tablets
New Books and Other Publications
New Meetings
Merck Sues SmithKline Beecham Over Chickenpox Vaccine
beta-Interferon European Patent Revoked
Highlights of U.S. Patents
Large Trial Shows AZT/DDC/Saquinavir Better Than AZT/DDC
3TC Receives Full FDA Approval for HIV-Infection
CMV Antisense Drug Shows Efficacy for Intractable CMV Retinitis
President Clinton Calls for AIDS Vaccine Development
Roche Acquires Boehringer Mannheim
Schering-Plough and Corvas Link to Develop Hepatitis C Drugs
Lilly and Vertex Link to Develop Hepatitis C Drugs
Schering-Plough Resolves Structure of Hepatitis C Virus Helicase
LXR Biotechnology Drops U.S. Development of HIV Apoptosis Diarrhea Drug
GPI-2A, Liposomal HIV Antisense Drug, Enters Clinical Trials
DMP 266 Continues to Show Promise for HIV-Infection
Famciclovir Shows Efficacy for HSV in HIV-Infected Patients
Ribozyme Pharmaceuticals Links with Schering AG
Opportunistic Infections Affect Macrophage Reservoirs of HIV-Infection
Activated Lymphocyte Trial for HIV-Infection
Another Trial Shows Promise for MEDI-493, RSV Monoclonal Antibody
Merck Criticized for Trial with AZT Monotherapy Arm
Ganciclovir Eye Implant Approved in European Union
Ganciclovir Prodrug Development Continues
Triple HIV Drug Combination Delays CMV Retinitis
American Red Cross Signs Deals for Interferon Leukocyte Supply
CRADA for Preclinical Development of Anti-HIV Calanolides
Dr. Montagnier Moving to a U.S. Research Institute
HCV Protein Linked with Interferon Resistance
Chemokines Paradoxically Boost Replication of Some Strains of HIV
Interferon Sciences Links with Bergen Brunswig for Interferon U.S. Marketing
HIV Resistance Assay Available
Controversial ÒMorning-AfterÓ Drug Trial and Guidelines for HIV-Infection Treatment
First Study of PCR for Blood Screening
Borna Disease Virus Linked to Depression
Adding/Switching Nucleosides May Increase Mortality in Advanced HIV-Infection/AIDS
FDA Meeting Will Consider HIV RNA as Clinical Endpoint
Clinical Trials Insider Trading Case Involving Thymosin Alpha 1
FDA Warns of Diabetes Risk from HIV Protease Inhibitors
Paracelsian Cancels Impending Launch of Nutraceutical HIV Drug
New Books and Other Publications
Free Internet MEDLINE
HIV Therapy Patent Trends Reported
Bristol-Myers Squibb Licenses HIV Protease Inhibitors from Novartis
Highlights of U.S. Patents
Live Influenza Nasal Spray Vaccine Shown Effective in Phase III Pediatric Trial
Respiratory Syncytial Virus Monoclonal Antibody Effective in Phase III Trial
HIV Treatment Guidelines Published
J&J Withdraws Home HIV Test Kit
Humanized Antibody Shows Indications of Efficacy for CMV Prophylaxis in BMT
Triangle Pharmaceuticals Acquires Avid Corp.
Boycott of Popular Glaxo Wellcome Drugs Over Access to 1592U89
Kidney/Urinary Problems are Side Effects of Indinavir
Infant HIV Viral Load Changes and Viral Load Threshold Effect Reported
Ciba Vision Licenses Worldwide Rights to CMV Antisense Drug from Isis
Roche Licenses Asian Rights to Nelfinavir
Maxamine/Interferon-alpha Enters Trials for Hepatitis C
Vaccinia Vector HIV Vaccine Enters Prime-Plus-Boost Trial
Pleconaril Shows Efficacy Against Enteroviral Meningitis
Rotavirus Vaccine Enters Phase II Trials
1,1'-Azobisformamide Enters Trials for HIV-Infection
ArQule Links with University of California for HHV-8 and HIV Protease Inhibitors
RBC-CD4 Phase I/II Trial Results
HIV Protease Inhibitor, 141W94, Enters Phase III Pediatric Trial
Generic Drug Company Obtains Acyclovir from Glaxo Wellcome
GS 4104 Enters Phase II Trials for Influenza
HIV Therapy Audit
Indinavir Leads HIV Protease Inhibitor Sales
Anti-HIV/STD Vaginal Gel Completes Phase I Trial
3TC/AZT More Effective in Children than DDI
Glaxo Wellcome Files for FDA Approval of AZT/3TC Combination Tablet
CEL-SCI Improves HIV Vaccine for Prophylaxis
RiboGene Extends Collaboration with Trega Biosciences
Trimeris Links with MiniMed for Antiviral Drug Infusion Systems
Hepatitis A Virus Vaccine Approved for New Indication
New Internet Resources
New Meetings
MedImmune Licenses Antibody Humanization from Protein Design Labs.
Michigan Biologic Products Inst. for Sale
Highlights of U.S. Patents
Lidakol Shown Effective for Oral Herpes in Phase III Trial
Hybridon Halts Development of GEM91; Developing New Antisense HIV Drug
Physicians and Activists Challenged to Volunteer for Live HIV Vaccine Trials
Infectious Hepatitis C Virus Cloned
Intravenous Hepatitis B Immune Globulin in Phase II Trials for Liver Transplants
Merck Pledges Full-Scale Development of Naked DNA HIV Vaccine
SKB Files for Famciclovir and Penciclovir Use in Immune Compromised Patients
RiboTargets, New U.K. HIV and HCV Drug Company
AIDS Epidemiology: Mortality Declines in the U.S., Incidence Increases Worldwide
Roche Files for Approval of PCR for HIV Treatment Monitoring
More HIV Chemokine Receptor/Infection Cofactor Discoveries
Ampligen Expanded Access for CFS with Cost Recovery Starts
1529U89 Open-Label Access Program Gets Underway
BioChem Pharma Links with Structural Bioinformatics for HCV Drug Design
AZT is Shown to Be a Poor Substrate for Thymidylate Kinase
First Filing for Approval of Lamivudine for Hepatitis B
New Phase II Trials with Once Daily DMP 266, an HIV NNRTI
Nevirapine Enters Trial for Perinatal HIV Transmission
Companies Report Increased HIV Drug Sales
Hepatitis B Vaccine Linked with Decrease in Pediatric Liver Cancer
Most HIV Patients Fail to Communicate with Physician
Childhood Immunization Rates Rise in U.S.
Pediatric Combination Vaccine with Hepatitis B Approved in European Union
Managed Care Having Problems Adopting New HIV Guidelines
Sequential Rather Than Combination HIV Drug Treatment
CMV and RSV Immune Globulins Approved in Canada
Rotavirus Phase II Trial
Matrix Licenses U.S. Marketing of AccuSite for Genital Warts to Altana
Low-Dose Oral Interferon HIV Trial Halted
New Publications
New Meetings
Virologix to License Topoisomerase I Inhibitors from NIH for HIV-Infection
Patent Infringement Suit Against AmgenÕs Consensus Interferon
Amarillo Biosciences Licenses Interferon
Highlights of U.S. Patents
Famciclovir Approved for Prevention of Genital Herpes
DMP 266ÑBenefits Continue at 48 Weeks; Expanded Access Program
Matrix Drops Effort to Market Genital Warts Drug in the U.S.
First Clinical Data for the New Saquinavir Formulation
Reports of Possible HIV Eradication with DDI/Hydroxyurea
WF10 Approved in Thailand for Treatment of HIV-Infection
ÒTrojan Horse VirusÓ Controls HIV In Vitro
Application Withdrawn for U.S. Approval of an Oral Polio Vaccine
Interferon-alfa-2b Plus Ribavirin Effective in Phase III Trials for Hepatitis C
Novel GM-CSF Adjuvant with HGP-30 HIV Vaccine Enters Trials
New Swine Hepatitis E Virus Related to Human Virus
Hepatitis A Vaccine Approved in Sweden
Oral HIV Antisense Drug, GEM 92, Enters Trials
Low Dose Oral Interferon/Injectable Interferon Trial for Hepatitis C
Mutant CCR5 is Not the Only Reason for HIV Nonprogression
Hybridon-Roche HPV/HCV Antisense Collaboration Ends; Hybridon Continues Efforts
HemaSure Halts SteriPath Viral Inactivation Development
Topical Anesthetic May Improve Genital Warts Surgery
Sheep HIV Immunotherapeutic Monoclonal Antibody Collaboration
MorphoSys Developing CMV Protein-Protein Interaction Map
Cloned Chemokine Receptors Available
Cuban HIV Vaccine Safe in Early Study
Phase III Trials with PEG-Interferon-alfa-2b for Hepatitis C
Even Brief Halt in Treatment Allows HIV Reseeding of Lymph Nodes
Oral Influenza Vaccine Safe in Phase I Trial
Asbestos-Related Lung Cancer Linked to SV40
Rubella Vaccine Not Associated with Joint Disease in Women
Goat Virus May Provide HIV Vaccine
Live Interferon-Expressing Oral SIV Vaccine
Monocytes in KaposiÕs Sarcoma Lesions are Infected with HHV-8
Chiron Links with AMRAD for HCV Screening
HemispheRx Links with Beaufour Ipsen for Hepatitis B Drug Development
Taxol Approved for KaposiÕs Sarcoma; Impending Orphan Drug Conflict
New Publications
New Meetings
HCV Patents Available for Protease Inhibitor Development
Thymosin Alpha 1 Granted Hepatitis C Use Patent in Europe
VION Amends Licenses with Yale Univ.
Highlights of U.S. Patents
Tracing U.S. Hepatitis C Infections from Pre-1992 Transfusions
Recombinant Consensus Interferon Approved for Chronic Hepatitis C
Valacyclovir Approved for Suppression of Genital Herpes
Indinavir/AZT/3TC Combination Continues to Show Efficacy at Two Years
Combivir, AZT/3TC Combination Tablet, Approved
Zanamivir Shows Efficacy for Treatment of Influenza
GS 4104 Shows Efficacy for Treatment and Prevention of Influenza
Oral/Implant Ganciclovir Combination Shows Prophylactic Efficacy
D4T Continues to Show Promise as Basis for HIV Drug Combinations
Famciclovir Reduces HSV-2 Shedding and Latency
Saquinavir Soft Gel Capsules Show Efficacy Comparable to Indinavir
Nevirapine, HIV NNRTI, Combinations Continue to Show Efficacy
HIV Protease Inhibitor Treatment Failures May Be More Common Than Trials Indicate
Four Drug Combination Shows Indications of Efficacy
New Phase III Trial for 141W94; Encouraging Phase II Results
D4T Approved for First-Line Use in Europe
Pediatric Filing for Interferon for Hepatitis B
HSV Vaccine Prophylactic Efficacy in Mice
ArQule and RiboGene Form Collaboration
Foscarnet Cream for Oral Herpes
Milder Influenza Season Forecast in U.S.
HIV Integrase Inhibitor Pharmacokinetic Trial
HIV Sequence-Based Genotyping Kits Available
MKC-442, HIV NNRTI, Continues to Show Activity
Viral ÒBiological SabotageÓ in New Zealand
Ritonavir/D4T Pediatric Efficacy
Australian RSV Drug Design Collaboration
Quidel and Glaxo Wellcome Link for HSV-2 Diagnostics
First FDA Approval for HCV Viral Load Assay
New Publications
New Meetings
OraVax Licenses Flavivirus Vaccine Technology and Rights to Yellow Fever Vaccine
Company Seeks Partners for Prophylactic Herpes Vaccine Development
Highlights of U.S. Patents
HIV Infection Persists Despite Triple Drug Combination Therapy
New Rabies Vaccine Approved
Ribavirin Increases Efficacy of Interferon for Hepatitis C
Fortovase, Saquinavir Soft Gel Capsule Approved by FDA
Trial to Test Valacyclovir for Reduction in Genital Herpes Transmission
KSHV/HHV-8 Expresses Chemokines with Anti-HIV Activity
United Nations Starts HIV Drug Access Program
Systemic Antiviral Effects with Low Dose Oral Interferon
Viragen Developing Topical Interferon for Genital Herpes
BMS Developing Drugs for Hepatitis B
Inconsistent Results with a Controlled Release Influenza Vaccine
Bausch & Lomb Acquires Chiron Vision and CMV Retinitis Eye Implant Product
RSV Monoclonal Antibody Phase III Trial Delayed for a Year
Aluminum-Based Vaccine Adjuvants Do Not Work as Generally Thought
Hepatitis B DNA Vaccine Needleless Injection Safe in Phase I Trial
U.S. Minorities Have Lesser Understanding of HIV and Its Treatment
New HIV Pathogenesis Mechanism
Timing of Infant Vaccinations Linked to Viral-Induced Diabetes
New Hepatitis E Virus Strain Found in U.S.
Cangene to Produce New Hepatitis B Immune Globulin Product for Nabi
Viral Load Benefits Seen with Treatment of Primary HIV Infection
Varicella-Zoster Virus Immune Globulin Post-Herpetic Neuralgia Trial Halted
Number of New U.S. HIV Patients on Triple Drug Therapy Doubles in Second Quarter
3TC Hepatitis B Warning Letter
Schering-Plough Commits to Thymosin alpha 1 Development for Hepatitis C in Japan
XQ-9302, Chinese Herbs, Enters U.S. Trial for HIV-Infection
1592U89 Expanded Access for AIDS Dementia
Controlled-Release Acyclovir Entering U.S. Trials
ArQule and ViroPharma Link for RNA Virus Drug Discovery
Valganciclovir CMV Retinitis Trials Expanded
Cell Culture Influenza Vaccine Enters Phase II/III Trials
MediChem Receives Award for Anti-HIV Calanolide A R&D
Novel Disinfection Systems Approved for Foods
Dr. Paul Resigns as Director, Office of AIDS Research, NIH
Antiviral Agents Bulletin Database Online; Sponsorship Opportunities Available
New Books
New Meetings
Merck Licenses Naked DNA Technology for HIV and Hepatitis B Vaccines
Mycogen Licenses Edible Plant Vaccine Technology
Highlights of U.S. Patents
Proposed Live HIV Vaccine Trials Face Many Problems
Hepatitis B Vaccine Shows Promise for Prophylaxis and Treatment
AZT Post-Exposure Prophylaxis Reduces Risk of HIV-Infection
Human Herpesvirus-6 Linked to Multiple Sclerosis
MedImmune Links with Abbott for RSV Monoclonal Antibody Marketing
Universal Vaccination with Chickenpox Vaccine Supported
Intracellular HIV Chemokine Gene Therapy
Epstein-Barr Virus Vaccine Enters Clinical Trials
HIVIG Trial for HIV Maternal Transmission Halted; AZT Efficacy Confirmed
BIRR 4 Shows Indications of Efficacy for the Common Cold
Bomb Attacks at BioChem Pharma
Dual Protease Inhibitor Therapy Suppresses HIV in the CNS
Trial with Ex Vivo Expanded, Sensitized CTLs for HIV-Infection
HPV Vaccine Shows Efficacy for Genital Warts
HIV Drug Regimen Compliance Predicts Viral Load Response
HPV Vaccine Shows Efficacy for Genital Warts at Six Months
Interferon-beta Gene Therapy for HIV-Infection
NDA for Intron A/Ribavirin Filed
HIV rev Gene Therapy Complements Drugs In Vitro
KSHV/HHV-8 Linked to Multiple Myeloma
Point Therapeutics Developing HIV Immune Restoration Treatments
Medicaid Coverage Will Not Be Expanded for HIV-Infection
Expanded Access Program for GS 840 for HIV-Infection
New Books and Other Information Sources
BMS and Arris Link for Hepatitis C Drugs; License Patents from Chiron
New Meetings
Highlights of U.S. Patents