Articles Published in 1996

Antiviral Agents Bulletin

FDA Approves Prophylactic Respiratory Syncytial Virus Immune Globulin
D4T Receives Full FDA Approval for HIV-Infection
Retrospective Study Links Plasma HIV Load to Clinical Efficacy
Abbott's HIV Protease Inhibitor Shows Clinical Efficacy; Submitted for Approval
Merck's HIV Protease Inhibitor Reduces Viral Load; Submitted for Approval
Plasma HIV Linked to Clinical Efficacy in Non-Nucleoside HIV RT Inhibitor Trials
Triangle Pharmaceuticals Links with Mitsubishi for HIV Drug Development
Topical Cidofovir Shows Efficacy for Anogential HSV in AIDS Patients
GS 840 Shows Indications of Efficacy Against HIV
Agouron's HIV Protease Inhibitor Enters Pivotal Phase II/III Trials
Ganciclovir and Foscarnet Combination More Effective
GS 930 (Cidofovir Prodrug) Enters Trial
Cidofovir Eyedrops Enter Trial
Ribozyme Gene Therapy Enters Trials
HIV Gene Therapy Trial Shows Safety
New Data Support Oral Ganciclovir Efficacy
Vertex Receives Milestone Payments
AZT Reduces HIV-Infection in Exposed Health Professionals
More Infants Found to Clear HIV-Infection
Kaposi's Sarcoma Herpesvirus Found in Semen
Corporate Name Changes
NIAID Publishes Report Backing HIV as Cause of AIDS
New Internet Web Sites
Generic Drug Companies and NIH Denied AZT Patent Appeal
Bristol-Myers Squibb Licenses Topical Lidakol for Oral Herpes
SKB Licenses EBV Vaccine from Aviron
Roche/Genentech Win alpha-Interferon Patent Interference
Cantab Options MPL Adjuvant for HPV Vaccines
Institut Pasteur Receives HIV-1 Western Blot License
Janssen Licenses Medeva's Hepatitis B Vaccine in Asia
Homeopathic Antiviral Available for Licensing
Ritonavir Receives Full and Accelerated Approvals for HIV-Infection Indications
Ganciclovir Eye Implant Approved for CMV Retinitis
Full Approval Recommended for First-Line DDI Monotherapy
Genentech Spins Off Company to Develop HIV gp120 Vaccine
Full Approval Recommended for First Line DDC/AZT
3TC Sales Take Off
NDA Filed for Nevirapine; Expanded Access Program Starting
Hepatitis B Gene Therapy R&D Program
NABI to Supply RSV Immune Globulin to MedImmune
D4T/DDI Combination Shows Efficacy
Protests Against HIV Protease Inhibitor Lottery in France
Saquinavir Unlikely to Result in Resistance to Other HIV Protease Inhibitors
Chiron Buys into Behringwerke AG Vaccines
Famciclovir Shows Efficacy for Genital Herpes in HIV-Infected Patients
Kaposi's Sarcoma Herpesvirus/HHV-8 Isolated
Agouron's HIV Protease Inhibitor Enters Phase III Trials
Injectable Gel for HPV Warts on Track for Approval in the U.K.
Intravenous Cidofovir Shows Efficacy for CMV Retinitis
D4T Recommended for European Union Approval
HIV Protease Inhibitor Combination Trial
NIAID/Chiron/Connaught Plan to Test "Prime-Plus-Boost" HIV Vaccine Protocol
NIH to Put More Emphasis on HIV Vaccines and Industry Collaboration
New Books
White House Meeting on AIDS Drug and Vaccine Development
New Meetings
NIH/GTI Gene Therapy Patent Interference Declared
Pasteur Merieux-Connaught Licenses Adjuvant
Merck's HIV Protease Inhibitor Approved; Drug Priced Lower Than Competitors
Hepatitis A Vaccine From Merck Receives FDA Approval
Immunotherapeutic VaxSyn HIV-1 gp160 Vaccine Shows No Benefit in Trial
Cell Genesys Testing Autologous T-Cell HIV Gene Therapy
Avid Developing HIV Protease Inhibitor Licensed from DuPont Merck
Hydroxyurea Plus DDI Shows Promise for HIV-Infection
Immunotherapeutic HIV Bispecific Antibody Shows Activity in Trial
HIV rev Gene Therapy Prolongs T-Cell HIV Resistance
HIV Antisense Drug Trials with New Injectable Formulation
Ciba-Geigy and Sandoz Merge to Form Novartis
Breakthrough Infection Observed with United Biomedical's HIV Vaccine
Thymosin Alpha 1 Showing Efficacy for Hepatitis B
Antiviral/HIV Pomegranate Extracts
Quidel and Glaxo Wellcome Developing Rapid Influenza Diagnostics
New Pediatric Dosage for Hepatitis A Vaccine From SKB
First Hepatitis B Virus Disinfectants Approved in U.S.
Topical Lidakol Phase III Trials for Oral HSV Fail to Show Efficacy vs. Placebo
HIV Immunotherapeutic Vaccine Trials in Thailand and U.S.
Delavirdine Expanded Access Program
Curcumin Fails to Show Anti-HIV Efficacy
Cambridge Biotech Corp. Selling Retroviral Diagnostics Business
T Cell Sciences and ArQule Screening Collaboration
Abbott and Medivir Form Collaboration
New Books
New Meetings
Calgene Wins Genetic Antisense Patent Dispute
Chiron and Ortho Settle HIV Patent Dispute
EPO Upholds Chiron's Hepatitis C Virus Patent
Hepatitis C Ribozymes and Animal Model Available for Licensing
Saquinavir/DDC Combination Improves Survival
Fusin Identified as Cofactor for HIV Entry
Controversies Over Pricing and Sales of Merck HIV Protease Inhibitor
Low-Dose Oral Interferon HIV-Infection Trial Starts After Long Delay
Second Trial Finds HIV gp160 Immunotherapeutic Vaccine Lacks Efficacy
Vaccines and Immune Activation Raise HIV Viral Load
ViroPharma and Chiroscience Form Hepatitis C and RNA Virus Drug Collaboration
RSV Monoclonal Antibody Enters Phase III Trials
HIV Prophylactic HIV DNA Plasmid Vaccine Enters Trials
Cidofovir Topical Gel Trials for HPV
Cidofovir CMV Trial Enrollment Halted Due to Efficacy; Approval Recommended
First HIV Protease Inhibitor Combination Trial
First Case of Hepatitis E Acquired in the U.S.
CTLs Have Novel Properties
Long-Term Follow-Up of HIV Immunotherapeutic Vaccine
Sales Increase for CMV and RSV Immune Globulins
Interferon Sciences Reacquires Alferon N Injection Rights
BioChem Therapeutic and Oncogene Science Link for Hepatitis C and HIV Drugs
Pasteur Merieux Expands Naked DNA Vaccine Collaboration with Vical
Massachusetts Requires Insurers to Pay for Off-Label Drug Uses
Physician Experience Influences AIDS Patient Survival
HIV Virus-Like Particle Vaccine Development Halted
Interferon Trial for HIV
Modified Milk Protein Active Against HIV; Promising for Vaginal Virucides
Glaxo Wellcome Reports 1995 Antiviral Drug Sales
Medeva Selects Influenza Vaccine U.S. Marketer
Clinical Trials Briefs
Liposomal Daunorubicin Approved for Kaposi's Sarcoma
Influenza Vaccine Recommendations
New Books
HIV/AIDS Information Outreach Project Web Server
HIV-DOCS Mailing List
Virology Web Site Expanded
Triangle Pharmaceuticals Licenses Three More Antiviral Drugs
Court Upholds Biogen in Hepatitis B Patent Dispute
PTO Supports Roche Interferon Patent
Highlights of U.S. Patents
HIV-1 Plasma Viral Load Assay Approved
Interim Recommendations for Use of HIV Plasma Load Data
VX-478 HIV Protease Inhibitor Trials
Hepatitis B Immunotherapeutic Vaccine Shows Indications of Efficacy
AccuSite Injectable Gel Approved in U.K. for Genital Warts
HPV Cervical Cancer Vaccine Induces Immune Responses
F-ddA Enters Trials for HIV-Infection
PMPA Shows Efficacy Against Sexually Transmitted and Chronic SIV
Oral Transmission of HIV; Throat a Major Site for HIV Replication
Antisense Gene Control of Viral Pathogens in Mosquitoes
NeXstar and Boehringer Mannheim Link for CMV and HIV Lipid Conjugate Drugs
HLA Genes Influence HIV Progression
Peptidoglycan Shows Antiretroviral Activity
Anti-HIV Efficacy Seen in First Cytokine Combination Trial
HIV Plasma Viral Load Better than CD4+ T-Cell Count
HemispheRx and Helix BioPharma Link for Ampligen Development
UN Clinical Trials with Nonoxynol-9 Product to Prevent HIV Transmission
Human Papillomavirus Vaccine from Merck Nearing Trials
Topical Cidofovir Shows Efficacy for Genital Herpes
Progesterone Increases Susceptibility to Sexual Transmission of SIV
AG1343 HIV Protease Inhibitor Trials Update
VIMRx Acquires German Company Developing Ribozymes
3TC Now Largest-Selling HIV Drug in the U.S
Reticulose Enters Trials for Genital Warts; Shows Anti-HIV Activity
Herbal HIV Protease Inhibitor/Immune Modulator Nutritional Supplement
Late Breaking News
Sorivudine Rejected by FDA Advisory Committee for Herpes Zoster
FDA Approves Improved DDI Formulation
New HIV Immunodiagnostics Approved by FDA
NIH RAC Exempts HIV Ribozyme Trial
New Meetings
CMV Treatment Training Internet Web Site
AIDS Reagent Catalog Now Online
CEL-SCI Acquires Adjuvant Technology for Its HIV Vaccine
Amgen Licenses Interferon to Yamanouchi for Hepatitis C and Other Indications
Sequus Options Liposome-CD4 from Sheffield Medical
BioChem Pharma Receives European Patent for 3TC/Lamivudine
MedImmune Licenses Parvovirus Vaccine Technology
Highlights of U.S. Patents
Cidofovir Injection Approved by FDA for CMV Retinitis
Nevirapine Receives Accelerated Approval for HIV-Infection
Aviremia with Agouron's HIV Protease Inhibitor
Second Cofactor for HIV Entry Identified
IL-2 Shows Promise for HIV-Infection
Thymosin Alpha 1 Showing Efficacy for HIV-Infection
Glaxo Wellcome's New Nucleoside HIV RT Inhibitor�Replacement for AZT?
HGP-30 HIV Vaccine Prophylactic Efficacy in Animal Model
Ritonavir HIV Protease Inhibitor Results Updated
Glaxo Wellcome and Vertex Commit to Developing HIV Protease Inhibitor
Good Results with Controlled Release AZT�Problem for Glaxo Wellcome?
Cantab and SKB Genital Warts Vaccine Collaboration
"Bloodbath" Protest at AIDS Conference
3TC/AZT/Indinavir Show Effects for Up to One Year
Dihydropyrone HIV Protease Inhibitors
KNI-272 HIV Protease Inhibitor Phase I Trial Results
Aaron Diamond Labs. Joins Rockefeller Univ.
AIDS Conference Abstracts Database
Free Internet Access to MEDLINE
New Meetings
RiboGene Licensing HIV Frameshifting Drugs from Warner-Lambert
MedImmune Licenses HPV Vaccine Technology
Highlights of U.S. Patents
3TC Shows Clinical Efficacy
Mutant CC-CKR-5 Receptor Gene Confers Protection Against HIV
Thymosin Alpha 1 Shows Efficacy for Hepatitis B
Pharmacia & Upjohn to Market CMV Drug, Cidofovir Injection, Internationally
Isis Reacquires Rights to ISIS 2922, CMV Antisense Drug
CMV Antisense Drug, GEM 132, Enters Trials
Pathogenic Molluscum Contagiosum Virus Sequenced
PCR as a Marker to Begin CMV Prophylaxis
Tree Extract SPV-30 Fails to Show Much Efficacy Against HIV
Can HIV-Infection be Eradicated from Infected Individuals?
KSHV/HHV-8 Further Linked to Kaposi's Sarcoma
HNK20 RSV Antibody Nose Drop Trial Results
Influenza Drug, Amantadine, Shows Promise for Hepatitis C
Nevirapine Costs
Warner-Lambert Acquires OTC Joint Venture from Glaxo Wellcome
New Phase III Trials with Lidakol for Oral Herpes
Phase III Trials with Natural Interferon for Hepatitis C and HIV
MedImmune Building Plant in Maryland
Forum for Collaborative HIV Research
Oncogene Science Receives Anti-HIV Screening Grant
Reduction of HIV-Infection in Thailand; Problem for Vaccine Trials?
International AIDS Vaccine Initiative
Innovir Links with Scripps to Study Hepatitis B Antisense Drugs
HIV Anti-Idiotype Immunotherapeutic Vaccine Shows Immunogenicity
3TC Approved in the European Union
Short Antisense Oligonucleotides Unexpectedly Effective In Vitro
Aquila Assumes Cambridge Biotech's Adjuvants/Vaccines
Inactivated HIV Vaccine Pediatric Trial
NDA Submitted for Delavirdine
First Urine HIV Diagnostic Approved
New NIAID HIV Clinical Trials
New Books
New Meetings
New Internet Web Sites and Databases
Court Rules Against Roche on Taq Polymerase Patent
3TC, Largest Selling HIV Drug, Patent Infringement Suit
NIH HIV-Related Licensing Opportunities
Penciclovir Cream Shown Effective for Oral Herpes
GS 840 Shows Indications of Efficacy for Hepatitis B
Genital Herpes Subunit Vaccine Efficacy Comparable to Drug Therapy
Famciclovir Efficacy for Recurrent Genital Herpes Prophylaxis
Thymosin Alpha 1 Approved in China for Hepatitis B
Oral Ganciclovir Shown Effective for CMV Prophylaxis in Liver Transplants
141W94 Shows Indications of Efficacy for HIV-Infection
HIV Protease Inhibitor Combination Shows Indications of Efficacy
Roche Links with Gilead for Influenza Drugs; GS 4104 Shows Promise
HIV NNRTI and Protease Inhibitor Combination Show Indications of Efficacy
Hepatitis A Vaccine Stops Epidemic
Chiron Alliance for Vaccine Distribution in the U.S.; Vaccine Company Renamed
Drug-Eradicated Live HIV Vaccines
DIAD Developing Promising HSV-1 Topical Prodrug
Nelfinavir HIV Protease Inhibitor Expanded Access Program
SKB Links with Arris for Viral Protease Inhibitors
Roche and Gilead to Co-Promote Interferon for Hepatitis C
Baxter to Acquire Immuno AG
Hepatitis B Immune Globulin Enters New Trials
SDF-1 is a Ligand for Fusin (HIV Entry Co-Factor)
Solvay to Co-Market Famciclovir for Genital Herpes
Ritonavir Approved in the European Union
Polio Vaccination Recommendations Changed in U.S.
Recombinant Human Growth Hormone Approved for AIDS Wasting
ICN Cleared of Some Ribavirin/HIV-Related Securities Fraud Charges
U.S. AIDS-Related News Coverage Has Become Less Scientific/Medical
New Books
New Meetings
Chiron and Murex Settle HCV Patent Dispute
Perkin-Elmer Licenses Diagnostic Uses of PCR
Highlights of U.S. Patents
IL-2 Doubles CD4+ T-Cell Count for Over a Year
Intranasal Influenza Virus Vaccine Shows Efficacy and Enters Phase III Trials
CMV Humanized Antibody Trial Halted; Others Continue
WF10 Shows Indications of Efficacy for HIV-Infection
Hepatitis C Virus NS3 Protease Structure Reported
Nucleotide Analog PMPA Enters Trials for HIV-Infection
Thymosin alpha 1 Shows Further Efficacy for Hepatitis B
Famciclovir May Be Better than Acyclovir for HSV-2; May Impact HSV Latency
HIV Integrase Inhibitor Phase I Trial and Monkey Studies
Hybridon Completes World-Class Plant for Antisense and Other Oligonucleotides
Oral Live Rotavirus Vaccine Induces Immune Response
Isis Reconfirms Efficacy of Antisense Drug for CMV Retinitis
Topical Bile Acids for HSV-2 Prophylaxis
CD8+ T-Cells Also Infected with HIV
HIV Whole-Body Hyperthermia Trials Resume
Reticulose HIV Trial
Hypericin Anti-HIV Dosage Determined
First Analysis of Thai Remune HIV Vaccine Trials
Anti-HIV Plant Drug in Phase II Trials
Steroids Not Effective or Appropriate for CFS
Ten-Year Ribavirin-Related Suit Against ICN Ends
RANTES Mimic is Active Against HIV
Apollon Sues Over Genentech's HIV Vaccine Company Name
VP 63843 Shows Indications of Efficacy Against Coxsackievirus
Hepatitis B Vaccine Improved Immunogenicity in Neonates
CMV Protease Structure Reported
FDA Approves Penciclovir Cream for Oral Herpes
Toxicity Report with New CMV Drug Prompts Strong Company Response
New Meetings
Anti-HIV 1592U89 Technology Transfer
Highlights of U.S. Patents
Famciclovir Shows Efficacy for Chronic Hepatitis B
Lamivudine Shows Indications of Efficacy for Hepatitis B
Thymosin Alpha 1/Interferon Combination Shows Efficacy for Hepatitis C
HIV Can Be Reduced to Undetectable Levels in Lymphoid Tissue
1263W94 from Glaxo Wellcome Entering Phase II Trials for CMV
New Adjuvant Enters Trials with Influenza Vaccine
HIV Load�How Low to Go?
Update on Saquinavir Resistance
Agouron Filing NDA for Nelfinavir Approval
Warning Against Combining Rifamycins with HIV Protease Inhibitors
BIV/HIV Vaccine Trial Problems in India
HIV Immunotherapeutic Vaccine/Multiple Drug Combination Trials
ACTG 175 and CPCRA 007 Results Published
Watson Pharm. Acquiring Oclassen Pharm.
Brazil Providing HIV Drugs Free
CEL-SCI Developing HSV Vaccine
IL-12 Reduces HIV Cellular Immunity
IL-10 in Phase I Trial for HIV-Infection
Remune HIV Vaccine Expanded Access Program
Nelfinavir/Saquinavir/Nucleoside Analogs Combination Trial
MIP-1a Chemokine Entering Trials
European HIV Drug Approvals
HIV Integrase Inhibitor Trials Progress
Activists Protest HIV Drug Prices
Herpes Simplex Virus Entry Mediator Identified
WSJ Article About 1592U89
Problems with HIV Protease Inhibitor Supply Continue
Music Boosts Secretory Immunity
BioChem Pharma Extends Link with XTL for HCV Drug Development
Amantadine Capsules Reintroduced
Warning�Delavirdine/HIV Protease Inhibitor Combinations
First HIV Dementia Model
FDA Approves Hepatitis B Combination Vaccine
New AZT Dosage Approved
Institute of Human Virology Starts New Journal
Biogen's Hepatitis B Virus Patent Ruled Invalid in U.K.
European Patent for Taq Polymerase
Thymosin Alpha 1 Licensing Expanded
U.S. Patent Office Biotech Patent Backlog
PEG-Interferon Licensed to Schering
Highlights of U.S. Patents
Interferon alpha-2a Approved for Chronic Hepatitis C
Oral Ganciclovir Approved for Prevention of CMV Disease in Transplant Recipients
Plant-Derived HIV Protein-Tyrosine Kinase Inhibitor Shows Indications of Efficacy
HPV Vaccine Shows Indications of Efficacy for Genital Warts
Humanized Respiratory Syncytial Virus Antibody in Phase III Trial
Herpes Simplex Virus Subunit Vaccine Development Halted by Chiron
HIV NNRTI/Nucleosides Combination Shows Indications of Efficacy
New Data Show Importance of AZT to Reduce Maternal Transmission of HIV
HIV Rev M10 Gene Therapy from SyStemix Enters Trials
Human Hepatitis B Virus Antibody Enters Phase II Trials
Polio Vaccine Controversies Continue in the U.S.
SRA Technologies Forms Collaboration for Drug Evaluation Methods
Herpes Simplex Virus DNA Vaccine Enters Trials
Cuban HIV Vaccine to Enter Trials
LeukoSite and Warner-Lambert Link for CCR-5 HIV-Infection Blockers
Hepatitis B Immunotherapeutic Vaccine More Effective at Lower Viral Loads
Agouron Files for Approval of Nelfinavir for HIV-Infection
VIMRx Acquiring Innovir, Consolidating Ribozyme Technologies
Reticulose Anti-HIV Trial Results
Hepatitis A/B Vaccine Approved in Europe
Hepatitis G Virus Diagnostics Available
Cimetidine Lacks Efficacy for HIV-Infection
Influenza Vaccine from Warner-Lambert Recalled
FDA Antiviral Advisory Committee Fails to Recommend Delavirdine Approval
Dr. D. Baltimore to Head NIH HIV Vaccine Efforts
FDA Approves Lymphocyte Adhesion Antibody Trials for HIV-Infection
New Meetings
New Books
New Internet Web Sites
Schering Charges Amgen with Interferon Patent Infringement
Lidak Reacquires Rights to Lidakol Cream
Novartis Merger Opens Access to HSV tk Gene Therapy Technologies
Highlights of U.S. Patents